Alexander B. Saltzman

Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes

This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.

Intermolecular disulfide bond formation promotes Hsp42 higher-order assembly and shapes client selection in yeast

This study shows that oxidation of Cys127 in Hsp42 promotes disulfide bond formation, oligomerization, and client selection in yeast under oxidative stress.

EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1-null Mice

This study shows that deleting EGR3 in Kcna1-null mice rescues seizures, behavior, and brain pathology, linking early seizures to long-term transcriptional changes.

Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection

This study shows that Tamm-Horsfall protein enhances neutrophil NETosis during UTI by modulating respiratory chain, granules, and chromatin remodeling pathways.

Deep learning prediction boosts phosphoproteomics-based discoveries through improved phosphopeptide identification

DeepRescore2 improves phosphopeptide identification using deep learning, leading to more phosphosites detected and new biological insights in liver cancer.

Partial loss of CFIm25 causes aberrant alternative polyadenylation and learning deficits

The paper shows that partial loss of CFIm25, a protein regulated by NUDT21, causes learning deficits and molecular changes in neurons.

MiR-146a wild-type 3’ sequence identity is dispensable for proper innate immune function in vivo

This study shows that 3' sequence identity is not required for the established function of miR-146a in myeloid cells in vivo.