Antrix Jain

Pathogenic mutations in ATAD3A cause dysregulation of RagC/D-TFEB axis and disrupt lysosomal homeostasis

This study shows that pathogenic ATAD3A mutations disrupt the RagC/D-TFEB axis, leading to lysosomal dysfunction and neurodevelopmental defects.

Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes

This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.

Characterizing Excretory-Secretory Products Proteome Across Larval Development Stages in Ascaris suum

This study characterizes the excretory-secretory proteome of Ascaris suum larvae across developmental stages to identify potential therapeutic targets for ascariasis prevention.

EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1-null Mice

This study shows that deleting EGR3 in Kcna1-null mice rescues seizures, behavior, and brain pathology, linking early seizures to long-term transcriptional changes.

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.

Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-IbΔC-X Mice with Persistent Atrial Fibrillation

This study identifies proteomic changes in CREM-IbΔC-X transgenic mice with persistent atrial fibrillation, showing a shift from metabolic to profibrotic gene expression programs with age.

Activity-dependent induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation

The paper shows neuronal activity induces Slc22a3 in astrocytes, which affects histone serotonylation and GABA release, leading to olfactory deficits.

A truncating mutation of Magel2 in the rat modelled for the study of Schaaf-Yang and Prader-Willi syndromes alters select behavioral and physiological outcomes

This study generates and characterizes a rat model with a truncating Magel2 mutation, revealing altered behavioral and physiological traits consistent with human neurodevelopmental disorders.

MiR-146a wild-type 3’ sequence identity is dispensable for proper innate immune function in vivo

This study shows that 3' sequence identity is not required for the established function of miR-146a in myeloid cells in vivo.