Overabundant endocannabinoids in neurons are detrimental to cognitive function
Dexiao Zhu, Jian Zhang, Xiaokuang Ma, Mei Hu, Fei Gao, Jack Hashem, Jianlu Lyu, Jing Wei, Yuehua Cui, Shenfeng Qiu, Chu Chen
The paper shows that inhibiting neuronal 2-AG metabolism impairs cognitive function in mice, while astrocytic inhibition can counterbalance these deficits.
bioRxiv · Sep 17, 2024 · PreprintNeuroscience