Jian Zhang

This study shows that inhibiting MAGL in astrocytes reduces seizures and neuroinflammation by activating CB1-PPAR-γ signaling, preserving synaptic function and preventing cognitive decline in epilepsy.

This study identifies astrocytic monoacylglycerol lipase (MAGL) as a therapeutic target for Alzheimer's disease, showing that its inactivation reduces pathology and improves cognition in transgenic mice.

This paper develops a machine learning model to predict radiosensitivity in nasopharyngeal carcinoma using gene expression data and validates its association with immune characteristics and signaling pathways.

The paper shows that inhibiting neuronal 2-AG metabolism impairs cognitive function in mice, while astrocytic inhibition can counterbalance these deficits.

BEST provides a web tool for comprehensive biomarker analysis in solid tumors using large-scale, multi-cohort data with standardized annotations and diverse analytical functions.

SurvivalML is a web platform that helps develop and validate prognostic models across multi-center cancer datasets by providing tools for data processing, model training, and evaluation.

The paper identifies HOXA-AS3 as a long non-coding RNA that promotes castration-resistant prostate cancer progression through the miR-29b-3p/Mcl-1/STAT3 axis.

CAMOIP provides a web tool for analyzing multi-omics data related to immunotherapy across cancers, enabling biomarker screening and mechanism analysis in over 4000 patients.