Author

Jianlu Lyu

The University of Texas at San Antonio Health Science Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chu CheniD· 3 shared Dexiao Zhu· 3 shared Jian ZhangiD· 3 shared Mei HuiD· 3 shared Li Sun· 2 shared Mingzhe PaniD· 2 shared Chudai ZengiD· 1 shared Fei GaoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Chu ChenORCID

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Author profile →

3 papers

Recent·Most cited

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure Sequelae

Chudai Zeng, Fei Gao, Mei Hu, Jian Zhang, Dexiao Zhu, Li Sun, Jianlu Lyu, Mingzhe Pan, Chu Chen

This study shows that inhibiting MAGL in astrocytes reduces seizures and neuroinflammation by activating CB1-PPAR-γ signaling, preserving synaptic function and preventing cognitive decline in epilepsy.

Journal of Neuroinflammation · May 27, 2026Peer-reviewedNeuroscience

Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer Disease Therapy

Li Sun, Mei Hu, Jianlu Lyu, Dexiao Zhu, Fei Gao, Mingzhe Pan, Jian Zhang, Chu Chen

This study identifies astrocytic monoacylglycerol lipase (MAGL) as a therapeutic target for Alzheimer's disease, showing that its inactivation reduces pathology and improves cognition in transgenic mice.

bioRxiv · Dec 9, 2025 · PreprintNeuroscience

Overabundant endocannabinoids in neurons are detrimental to cognitive function

Dexiao Zhu, Jian Zhang, Xiaokuang Ma, Mei Hu, Fei Gao, Jack Hashem, Jianlu Lyu, Jing Wei, Yuehua Cui, Shenfeng Qiu, Chu Chen

The paper shows that inhibiting neuronal 2-AG metabolism impairs cognitive function in mice, while astrocytic inhibition can counterbalance these deficits.

bioRxiv · Sep 17, 2024 · PreprintNeuroscience