Shenfeng Qiu

Neuropil aggrecan, not perineuronal nets, closes the critical period for visual plasticity

This study shows that aggrecan in excitatory neurons, not perineuronal nets, limits visual plasticity by closing the critical period in adult mice.

Cognitive function depends upon Satb2 gene dosage in cortical projection neurons

This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.

Erythropoietin Mediates Glycerophospholipid Remodeling During Human Early Erythropoiesis

This study identifies erythropoietin's role in regulating glycerophospholipid metabolism during human erythropoiesis using single-cell transcriptomics and lipidomics.

Transcriptional Profiling of D1-MSNs Reveals SIRT1-Dependent and -Independent Responses to Chronic Social Defeat Stress

This study uses cell-type-specific transcriptomics to show that SIRT1 modulates depression susceptibility in D1-MSNs through metabolic and circadian pathways under chronic social defeat stress.

Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

This study identifies an Epo-dependent CFU-E subtype, lateC, characterized by CD71hiCD105hi phenotype and its role in erythropoiesis.

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.

Overabundant endocannabinoids in neurons are detrimental to cognitive function

The paper shows that inhibiting neuronal 2-AG metabolism impairs cognitive function in mice, while astrocytic inhibition can counterbalance these deficits.

Activity of prefrontal cortex serotonin 2A receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug DOI in a sex-dependent manner

This study shows that activating prefrontal cortex 5-HT2AR neurons alone does not induce head-twitch responses in mice, but their inhibition prevents DOI-induced responses, with sex-dependent effects.