Author

Jack Hashem

The University of Texas at San Antonio Health Science Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew D. RhimiD· 1 shared Chu CheniD· 1 shared Dexiao Zhu· 1 shared Dhwani N. RupaniiD· 1 shared Fei GaoiD· 1 shared Florencia M. McAllisteriD· 1 shared Fredrik I. ThegeiD· 1 shared Hajar RajaeiiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Andrew D. RhimORCID

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2 papers

Recent·Most cited

Overabundant endocannabinoids in neurons are detrimental to cognitive function

Dexiao Zhu, Jian Zhang, Xiaokuang Ma, Mei Hu, Fei Gao, Jack Hashem, Jianlu Lyu, Jing Wei, Yuehua Cui, Shenfeng Qiu, Chu Chen

The paper shows that inhibiting neuronal 2-AG metabolism impairs cognitive function in mice, while astrocytic inhibition can counterbalance these deficits.

bioRxiv · Sep 17, 2024 · PreprintNeuroscience

Adar1 deletion causes degeneration of exocrine pancreas via Mavs-dependent interferon signaling

Dhwani N. Rupani, Robert W. Cowan, Fredrik I. Thege, Vidhi Chandra, Sonja M. Wörmann, Hajar Rajaei, Prerna Malaney, Olivereen Le Roux, Sara L. Manning, Jack Hashem, Jennifer M. Bailey, Florencia M. McAllister, Andrew D. Rhim

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.

Development · Dec 2, 2022Peer-reviewedDevelopmental Biology