Cell BiologyMolecular CellPeer-reviewed
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase
Sara Carrillo Roas, Yuichi Yagita, Paul V. Murphy…·Ramanujan S. Hegde
The paper identifies the UBR4-KCMF1 ubiquitin ligase complex as a convergence point for quality control pathways that degrade orphan subunits, highlighting its role in protein homeostasis and cancer vulnerability.
20 citationstop 3%