Tim Clausen

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

The paper identifies a conserved selective autophagy receptor, CESAR, critical for proteostasis under heat stress in plants through cross-species interactome analysis.

The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.

This study identifies myosin misfolding as a driver of HCM using a fluorescent reporter and C. elegans model, showing dietary restrictions can reverse defects via autophagy.

The paper identifies the UBR4-KCMF1 ubiquitin ligase complex as a convergence point for quality control pathways that degrade orphan subunits, highlighting its role in protein homeostasis and cancer vulnerability.

The paper identifies TRIM52 as a primate-specific DNA repair factor under tight proteolytic control by BIRC6, HUWE1, and UBR4/KCMF1.

This study elucidates how McsB, a bacterial kinase, regulates protein degradation by switching between open and closed oligomer forms in response to stress.