Author

R. Kurzbauer

Research Institute of Molecular Pathology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Meinhart· 2 shared T. Clausen· 2 shared A. Shulkina· 1 shared D. B. Grabarczyk· 1 shared D. Haselbach· 1 shared D. M. Hoi· 1 shared Eszter ZavodszkyiD· 1 shared F. E. Morreale· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Meinhart

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Author profile →

3 papers

Recent·Most cited

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase

Sara Carrillo Roas, Yuichi Yagita, Paul V. Murphy, R. Kurzbauer, Tim Clausen, Eszter Zavodszky, Ramanujan S. Hegde

The paper identifies the UBR4-KCMF1 ubiquitin ligase complex as a convergence point for quality control pathways that degrade orphan subunits, highlighting its role in protein homeostasis and cancer vulnerability.

Molecular Cell · Jan 28, 2025Peer-reviewedCell Biology

Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen

The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

BacPROTACs mediate targeted protein degradation in bacteria

F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen

This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.

bioRxiv · Jun 9, 2021Biochemistry