Production of Offspring from Azoospermic Mice with Meiotic Failure: Precise Biparental Meiosis within Halved Oocytes
Narumi Ogonuki, Hirohisa Kyogoku, Toshiaki Hino, Yuki Osawa, Yasuhiro Fujiwara, Kimiko Inoue, Tetsuo Kunieda, Seiya Mizuno, Hiroyuki Tateno, Fumihiro Sugiyama, Tomoya S. Kitajima, Atsuo Ogura
This study shows that reducing ooplasmic volume in oocytes improves meiotic accuracy and embryo development, enabling offspring production from azoospermic mice with spermatocyte arrest.
EMBO Reports · May 19, 2022Peer-reviewedDevelopmental Biology