Cohesin constrains histone modification-driven chromatin dynamics
Takeshi Fujino, Yotaro Ochi, Susumu Goyama, Yuko Shimosato, Shiori Shikata, Ayana Kon, Takuto Mori, Toyonori Sakata, Hiroaki Honda, Haruhiko Koseki, Manabu Nakayama, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa, Toshio Kitamura
This study shows that mutations in Asxl1 and Stag2 cause dysregulation of histone modifications and chromatin structures, leading to aberrant gene upregulation and myelodysplastic syndromes.
bioRxiv · Dec 16, 2025 · PreprintCancer Biology