Manabu Nakayama

This study shows that mutations in Asxl1 and Stag2 cause dysregulation of histone modifications and chromatin structures, leading to aberrant gene upregulation and myelodysplastic syndromes.

The paper shows chronic heterochromatin loss in neurons leads to ERV de-repression, inflammation, and cognitive decline in mice.

This study shows KDM2 proteins repress transcription from CpG island promoters without relying on their histone demethylase activity.

The paper identifies FBXL19 as a CpG island-binding protein that recruits CDK-Mediator to developmental gene promoters in mouse ES cells, priming them for activation during lineage commitment.