Heterotypic Aβ interactions facilitate amyloid assembly and modify amyloid structure
Katerina Konstantoulea, Patrícia Silva Guerreiro, Meine Ramakers, Nikolaos N. Louros, Liam D. Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F. Ribeiro, Joris de Wit, Wei‐Feng Xue, Joost W. H. Schymkowitz, Frédéric Rousseau
This study shows heterotypic interactions between Aβ APRs and homologous protein segments accelerate Aβ assembly, alter fibril morphology, and are enriched in AD plaques but not in mouse models.
The EMBO Journal · Nov 29, 2021Peer-reviewedNeuroscience