Katerina Konstantoulea

This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.

This study shows TAF15 forms amyloid fibrils and propagates prion-like between cells, identifying specific motifs that drive its aggregation in vitro and in cells.

The paper determines the atomic structure of insect chorion amyloid filaments and reveals their assembly principles, showing functional amyloids can operate in a regulated biological context.

This study uses generative protein design to explore how sequences encode amyloid fibril structures, showing a continuous compatibility between sequences and a common amyloid fold.

Amyloid Explorer provides a standardized, thermodynamically annotated atlas of amyloid fibril structures, revealing conserved assembly rules and enabling mechanistic insights.

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

This paper identifies two VHH antibodies that selectively bind pathogenic tau seeds in AD and related tauopathies, showing potential for therapeutic and diagnostic applications.

This study shows heterotypic interactions between Aβ APRs and homologous protein segments accelerate Aβ assembly, alter fibril morphology, and are enriched in AD plaques but not in mouse models.

The paper shows viral ligand-receptor interactions enhance the spread of protein misfolding via extracellular vesicles and direct cell contact.