Nikolaos N. Louros

An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism

This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.

TAF15 amyloids propagate via defined motifs in a prion-like fashion

This study shows TAF15 forms amyloid fibrils and propagates prion-like between cells, identifying specific motifs that drive its aggregation in vitro and in cells.

A functional amyloid scaffold shapes insect egg coats

The paper determines the atomic structure of insect chorion amyloid filaments and reveals their assembly principles, showing functional amyloids can operate in a regulated biological context.

Reverse-engineering amyloid strains with generative protein design

This study uses generative protein design to explore how sequences encode amyloid fibril structures, showing a continuous compatibility between sequences and a common amyloid fold.

Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

The paper uses energetic profiling on cryo-EM data to uncover thermodynamic principles governing amyloid fibril maturation and polymorphic divergence.

Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles

Amyloid Explorer provides a standardized, thermodynamically annotated atlas of amyloid fibril structures, revealing conserved assembly rules and enabling mechanistic insights.

Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems

This study determines the cryo-EM structures of Aβ40 and medin fibrils in vitro, revealing polymorphic remodeling and mixed amyloid interactions.

Selective Targeting of Pathogenic Tau Seeds via a Novel VHH

This paper identifies two VHH antibodies that selectively bind pathogenic tau seeds in AD and related tauopathies, showing potential for therapeutic and diagnostic applications.

N-glycosylation as a eukaryotic protective mechanism against protein aggregation

This study shows N-glycosylation prevents protein aggregation by steric hindrance, especially in proteins prone to misfolding, using computational and biochemical analyses.

A structural analysis of amyloid polymorphism in disease: clues for selective vulnerability?

This paper analyzes amyloid polymorphism structure to explain disease-related stability and polymorphic bias, identifying conserved structural frameworks and templating interactions that influence cellular vulnerability.

EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

Heterotypic Aβ interactions facilitate amyloid assembly and modify amyloid structure

This study shows heterotypic interactions between Aβ APRs and homologous protein segments accelerate Aβ assembly, alter fibril morphology, and are enriched in AD plaques but not in mouse models.