Joris de Wit

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

The paper identifies molecular and developmental diversity in CA1 border inhibitory neurons and shows their postnatal emergence of retrosplenial connectivity.

This study identifies ICAM5 as a neuroligin interactor that drives dendritic growth through actin remodeling by sustaining PAK-Cofilin signaling.

The paper identifies VCAM1 as an astrocytic regulator of hippocampal synapse development through cross-modal analysis combining single-cell spatial transcriptomics and protein-level profiling.

The paper uses an intrabody-guided proximity-labeling strategy to map postsynaptic proteomes in hippocampal CA1 pyramidal neurons and identifies early synaptic remodeling in an Alzheimer's disease mouse model.

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

This study determines the trimeric structures of FAM171A1 and FAM171A2 extracellular domains, revealing a novel structural superfamily and their oligomerization properties.

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

The paper compares enhancer codes of cell types between mammalian neocortex and avian pallium using deep learning, finding higher divergence in excitatory neurons than other cell types.

The paper identifies distinct synaptic protein signatures and disease vulnerabilities in L5 IT and PT neurons, with autism risk genes enriched in L5 IT neurons.

The paper identifies TAOK2β as a regulator of translational elongation and shows its disruption leads to increased protein synthesis in an ASD mouse model.

This study identifies LRRC37B as a human-specific gene that modulates neuronal excitability by interacting with voltage-gated sodium channels in cortical pyramidal neurons.

The paper shows MDGAs delay excitatory synapse development by altering neuroligin behavior through fast diffusion and reduced mobility.

HyDrop is a droplet microfluidic platform for scATAC-seq and scRNA-seq that improves throughput and sensitivity while reducing cost.

This study shows heterotypic interactions between Aβ APRs and homologous protein segments accelerate Aβ assembly, alter fibril morphology, and are enriched in AD plaques but not in mouse models.

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

The paper identifies IgSF8 as a regulator of hippocampal CA3 microcircuit development by analyzing cell-surface protein composition and synaptic interactions.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

This study identifies SorCS1's role in maintaining axonal surface polarization of neurexin by regulating its trafficking and endosomal sorting.