Excitatory neurons as the default fate in bifurcation of excitatory and inhibitory neuron lineages
mei wang, Xiao-Ying Qiu, Yun-Bin Duan, Xia Tang, Qi Lu, Yan Li, Huiwen Qin, Xing-Tao Long, Mengmeng Jin, Peng-Yu Fan, Hui Zhang, Yanan Li, Jie He
The paper identifies a conserved genetic program where excitatory neuron fate is the default in EX-IN lineages, with Notch signaling enabling inhibitory fate.
bioRxiv · Oct 29, 2025 · PreprintDevelopmental Biology