Jie He

This study maps POAG risk variants to candidate effector genes in ocular cell types, identifying ARHGEF12 as a potential target.

The paper identifies cxcl18b-defined transitional states in zebrafish Muller glia that drive cell-cycle re-entry after retinal injury, with nitric oxide playing a key regulatory role.

The paper identifies a conserved genetic program where excitatory neuron fate is the default in EX-IN lineages, with Notch signaling enabling inhibitory fate.

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

The paper reveals how locus coeruleus-norepinephrine neurons organize to regulate brain-wide neural dynamics through region-specific axon projections and synchronized firing.

The paper creates a comprehensive atlas of larval zebrafish neuron morphology, including excitatory and inhibitory identities and connectivity patterns.

This paper shows that Piezo1 and Piezo2 channels are expressed in retinal ganglion cells and that their activation increases light-dependent neural activity and excitability, potentially linking to glaucoma progression.

The paper identifies regional gene expression heterogeneity in quiescent Müller glia in zebrafish retina and shows distinct activation patterns following photoreceptor ablation.

This study identifies Her6 and Prox1 as regulators of photoreceptor regeneration in zebrafish retina, showing they cross-regulate to promote differentiation.

This paper develops a new genetically encoded fluorescent cAMP indicator, G-Flamp1, which shows high sensitivity, brightness, and fast response kinetics for in vivo cAMP imaging.

This study develops a reproducible method to differentiate iPSCs into RGCs with high purity using dual SMAD and Wnt pathway inhibition.

The paper uses single-cell in vivo imaging to show light-initiated circadian oscillators in zebrafish, revealing that light exposure initializes cellular clocks during development.

The paper identifies a novel POAG-associated SNP in African Americans using a genome-wide association study.

This study shows that Cdk1 interacts with Cyclin A2 to phosphorylate Top2a, enabling S phase entry, and with Cyclin B1 to regulate M phase progression in zebrafish embryos.