Yan Li

This study identifies MeCP2's interaction with the super elongation complex and shows it regulates transcription by modulating RNA polymerase II binding and gene expression.

The paper identifies a conserved genetic program where excitatory neuron fate is the default in EX-IN lineages, with Notch signaling enabling inhibitory fate.

TWO-SIGMA is a single-cell RNA-seq differential expression method that handles drop-out, overdispersion, and within-sample correlation, outperforming existing methods in simulations and real data.

This study presents the first high-quality genome assembly of Antirrhinum majus, revealing evolutionary relationships and genetic architectures of complex traits.