Mengmeng Jin

This study uses human brain organoids to show that transient IL-6 exposure during prenatal development disrupts interneuron maturation and subtype specification, linking it to neurodevelopmental disorders.

This study shows that NEUROG2 can reprogram human microglial lineage cells into neurons both in vitro and in vivo, revealing a new pathway for neuronal replacement.

The paper identifies a conserved genetic program where excitatory neuron fate is the default in EX-IN lineages, with Notch signaling enabling inhibitory fate.

This study uses human-mouse chimeric brain models to investigate glial-neuronal and macroglial-microglial interactions, revealing key molecular mechanisms and dynamic cellular behaviors.

This paper introduces a trisomy 21-linked CSF2RB mutation in microglia that reduces neuroinflammation and enhances phagocytic functions, offering potential for AD therapy.

This study develops a human brain organoid model with controllable microglia ratios to better model brain development and pathology.