Co-targeting Metabolic Neighbours Constraints Bacterial Adaptive Evolution
Dwipanjan Sanyal, Yun-Ti Chen, Carl Ho, Arthur McClelland, Sourav Chowdhury, Eugene I. Shakhnovich
This study identifies a dual-targeting strategy for bacterial adaptive evolution by inhibiting two metabolic enzymes in the folate pathway, demonstrating constrained evolutionary trajectories with Arbutin.
bioRxiv · Jun 6, 2026 · PreprintBiophysics