Sourav Chowdhury

Topological Complementarity Predicts Synergistic Drug Pairs in Branched Metabolic Networks.

The paper identifies synergistic drug pairs in branched metabolic networks by analyzing topological complementarity in the E. coli folate pathway.

Co-targeting Metabolic Neighbours Constraints Bacterial Adaptive Evolution

This study identifies a dual-targeting strategy for bacterial adaptive evolution by inhibiting two metabolic enzymes in the folate pathway, demonstrating constrained evolutionary trajectories with Arbutin.

Adaptive Landscapes of Plasmodium Falciparum Dihydrofolate Reductase Reveal Pathways to Antifolate Resistance

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

Navigating the Fitness Landscapes of Plasmodium falciparum Dihydrofolate Reductase: Evolutionary Insights into Antifolate Resistance

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

Entropy Changes in Water Networks Promote Protein Denaturation

This study identifies entropy changes in water networks as a mechanism for ion-induced protein denaturation, revealing an 'inverse hydrophobic effect' that promotes unfolding.

Empowering systems-guided drug target discovery with metabolic and structural analysis

This study combines machine learning with metabolic and structural analysis to identify specific drug targets from metabolomics data, using a case study of a DHFR-targeting antibiotic.