Author

Carl Ho

Harvard UniversityORCID 0000-0001-6438-6561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:metabolomics· 1

Frequent Co-Authors

Arthur McClellandiD· 1 shared Dwipanjan SanyaliD· 1 shared Eugene I. ShakhnovichiD· 1 shared Sourav ChowdhuryiD· 1 shared Yun-Ti Chen· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBiophysics

Arthur McClellandORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintJun 6, 2026

Co-targeting Metabolic Neighbours Constraints Bacterial Adaptive Evolution

Dwipanjan Sanyal, Yun-Ti Chen, Carl Ho…·Eugene I. Shakhnovich

This study identifies a dual-targeting strategy for bacterial adaptive evolution by inhibiting two metabolic enzymes in the folate pathway, demonstrating constrained evolutionary trajectories with Arbutin.

DOI 10.64898/2026.06.04.729935

E. colimetabolomics

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