Dwipanjan Sanyal

This study identifies a dual-targeting strategy for bacterial adaptive evolution by inhibiting two metabolic enzymes in the folate pathway, demonstrating constrained evolutionary trajectories with Arbutin.

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

The paper proposes a framework to identify diagnostic and therapeutic autoantibodies for neurodegenerative diseases and multiple sclerosis using statistical and structural analysis.