Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling
Mingrong Zuo, Shuxin Zhang, Siliang Chen, Yuze He, Junhong Li, Yufan Xiang, Yunbo Yuan, Tengfei Li, Wanchun Yang, Zhihao Wang, Wenhao Li, Ni Chen, Yuan Yang, Yunhui Zeng, Qing Mao, , Yan‐Hui Liu
This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.
Oncogene · Oct 24, 2025Peer-reviewedCancer Biology