Notch Controls Multiple Pancreatic Cell Fate Regulators Through Direct Hes1-mediated Repression
Kristian Honnens de Lichtenberg, Philip Allan Seymour, Mette Christine Jørgensen, Yung-Hae Kim, Anne Grapin‐Botton, Mark A. Magnuson, Nikolina Nakić, Jorge P. Ferrer, Palle Serup
This study identifies direct Hes1 target genes in pancreatic progenitor cells, revealing Notch signaling's role in repressing tip cell fate through repression of key regulators like Ptf1a and Gata4.
bioRxiv · Jun 1, 2018 · PreprintDevelopmental Biology