Author

Mette Christine Jørgensen

University of CopenhagenORCID 0000-0003-2833-7863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Palle SerupiD· 3 shared Philip Allan SeymouriD· 3 shared Kristian Honnens de LichtenbergiD· 2 shared Alison FarleyiD· 1 shared Anastasia I. KousaiD· 1 shared Anne Grapin‐BottoniD· 1 shared Anuska la Rosa Egeskov-MadseniD· 1 shared Caitlin ColliniD· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersDevelopmental Biology

Palle SerupORCID

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3 papers

Recent·Most cited

Developmental BiologyDevelopmental CellPeer-reviewedFeb 13, 2020

Jag1 modulates an oscillatory Dll1-Notch-Hes1 signaling module to coordinate growth and fate of pancreatic progenitors

Philip Allan Seymour, Caitlin Collin, Anuska la Rosa Egeskov-Madsen…·Palle Serup

This study shows Jag1 modulates oscillatory Dll1-Notch-Hes1 signaling in pancreatic progenitors to coordinate their growth and fate, with Jag1 also specifying most bipotent progenitors.

87 citationstop 4%

mouseexperimental assay

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Developmental BiologyDevelopmentPeer-reviewedJan 1, 2020

Canonical NOTCH signaling controls the early progenitor state and emergence of the medullary epithelial lineage in fetal thymus development.

Dong Liu, Anastasia I. Kousa, Kathy E. O’Neill…·Clare C. Blackburn

This study shows NOTCH signaling regulates early thymic epithelial progenitor cells and mTEC lineage emergence during fetal thymus development.

40 citations

mouseexperimental assay

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Developmental BiologybioRxivPreprintJun 1, 2018

Notch Controls Multiple Pancreatic Cell Fate Regulators Through Direct Hes1-mediated Repression

Kristian Honnens de Lichtenberg, Philip Allan Seymour, Mette Christine Jørgensen…·Palle Serup

This study identifies direct Hes1 target genes in pancreatic progenitor cells, revealing Notch signaling's role in repressing tip cell fate through repression of key regulators like Ptf1a and Gata4.

12 citations

mouseChIP-seq

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