HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against hypoxia-induced neuronal injury
Yuning Li, Mengyuan Guo, Zhengming Tian, Qianqian Shao, Yingxia Liu, Yakun Gu, Zirui Xu, Feiyang Jin, Xunming Ji, Jia Liu
This study identifies a PINK1-dependent mitophagy pathway activated by hypoxia through HIF-1α/STOML2 axis, which protects neurons and suggests intermittent hypoxia as a therapeutic strategy.
bioRxiv · Apr 16, 2025 · PreprintNeuroscience