Author

Mengyuan Guo

Capital Medical UniversityORCID 0000-0001-6178-5225Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jia LiuiD· 2 shared Qianqian ShaoiD· 2 shared Yakun GuiD· 2 shared Zhengming TianiD· 2 shared Zirui Xu· 2 shared Dongjun Wang· 1 shared Feiyang JiniD· 1 shared Feiyang JiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Jia LiuORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 23, 2025

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson' s Disease-like Pathogenesis in Vivo

Zhengming Tian, Zirui Xu, Mengyuan Guo…·Jia Liu

This study shows that non-phosphorylated α-synuclein drives Parkinson's disease-like pathogenesis in mice, contradicting the traditional view that phosphorylated α-synuclein is pathogenic.

DOI 10.64898/2025.12.21.695762

mousespatial transcriptomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 16, 2025

HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against hypoxia-induced neuronal injury

Yuning Li, Mengyuan Guo, Zhengming Tian…·Jia Liu

This study identifies a PINK1-dependent mitophagy pathway activated by hypoxia through HIF-1α/STOML2 axis, which protects neurons and suggests intermittent hypoxia as a therapeutic strategy.

DOI 10.1101/2025.04.16.649120

mousestatistical model

𝕏 PostBluesky