Jia Liu

This study shows that non-phosphorylated α-synuclein drives Parkinson's disease-like pathogenesis in mice, contradicting the traditional view that phosphorylated α-synuclein is pathogenic.

This study identifies a PINK1-dependent mitophagy pathway activated by hypoxia through HIF-1α/STOML2 axis, which protects neurons and suggests intermittent hypoxia as a therapeutic strategy.

This study uses a bacteriophage-derived peptide to control CBE activity, improving targeting precision and gene correction efficiency in a Marfan syndrome model.

The paper identifies OLFML3 as a rhinovirus-inducible IFN antagonist using surfaceome CRISPR screening, showing its role in suppressing innate immunity.

The paper identifies bacteriophage-derived peptides that allosterically inhibit CRISPR-Cas9 activity, reducing off-target effects while preserving on-target activity.