MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption
Lilia Kaustov, Alexander Lemak, Hong Wu, Marco Faini, Scott Houliston, Lixin Fan, Xianyang Fang, Hong Zeng, Shili Duan, Abdellah Allali-Hassani, Masoud Vedadi, Ruedi Aebersold, Yunxing Wang, Cheryl H. Arrowsmith
The paper investigates the dynamic structure of the MLL1 catalytic complex and shows it can be disrupted by pharmacological agents targeting specific interaction sites.
bioRxiv · Apr 26, 2018 · PreprintBiophysics