PhenoScreen: A Dual-Space Contrastive Learning Framework-based Phenotypic Screening Method by Linking Chemical Perturbations to Cellular Morphology
Shihang Wang, Qi Han, Weichen Qin, Lin Wang, Junhong Yuan, Yiqun Zhao, Pengxuan Ren, Yunze Zhang, Yilin Tang, Ruifeng Li, Zongquan Li, Wenchao Zhang, Shenghua Gao, Fang Bai
PhenoScreen predicts compound-induced phenotypic changes by linking chemical space to cellular morphology using contrastive learning, showing effectiveness in osteosarcoma and rhabdomyosarcoma.
bioRxiv · Oct 23, 2024 · PreprintBioinformatics