Author

Shihang Wang

ShanghaiTech UniversityORCID 0000-0002-4714-6504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Fang BaiiD· 2 shared Bo LiiD· 1 shared Bob ZhangiD· 1 shared Chengliang Liu· 1 shared Chu‐Xia DengiD· 1 shared Hao YangiD· 1 shared Junhong Yuan· 1 shared Lin WangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Fang BaiORCID

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3 papers

Recent·Most cited

MVCBench: A Multimodal Benchmark for Drug-induced Virtual Cell Phenotypes

Bo Li, Qing Wang, Shihang Wang, Bob Zhang, Yuzhong Peng, Pinxian Zeng, Chengliang Liu, Mengran Li, Ziyang Tang, Xiaojun Yao, Chu‐Xia Deng, Qianqian Song

MVCBench evaluates drug molecular and gene representation methods for predicting drug-induced multimodal cell phenotypes using transcriptomic and imaging data.

bioRxiv · Apr 24, 2026 · PreprintBioinformatics

PhenoScreen: A Dual-Space Contrastive Learning Framework-based Phenotypic Screening Method by Linking Chemical Perturbations to Cellular Morphology

Shihang Wang, Qi Han, Weichen Qin, Lin Wang, Junhong Yuan, Yiqun Zhao, Pengxuan Ren, Yunze Zhang, Yilin Tang, Ruifeng Li, Zongquan Li, Wenchao Zhang, Shenghua Gao, Fang Bai

PhenoScreen predicts compound-induced phenotypic changes by linking chemical space to cellular morphology using contrastive learning, showing effectiveness in osteosarcoma and rhabdomyosarcoma.

bioRxiv · Oct 23, 2024 · PreprintBioinformatics

Conformational Space Profile Enhances Generic Molecular Representation Learning

Lin Wang, Shihang Wang, Hao Yang, Shiwei Li, Xinyu Wang, Yongqi Zhou, Siyuan Tian, Lu Liu, Fang Bai

This paper introduces GeminiMol, a molecular representation model that incorporates conformational space profiles to improve performance on molecular property prediction and zero-shot tasks like virtual screening.

bioRxiv · Dec 14, 2023 · PreprintBioinformatics