Structural insights and mechanistic inhibition of Plasmodium falciparum dihydroorotate dehydrogenase by newly identified chemotypes
Japheth Kibet Ng'etich, Ryuta Ishii, Hina Yuasa, Ryo Hatanaka, Aiko Hattori, Jun-ichi Kishikawa, Endah Dwi Hartuti, Normalita Eka Pravitasari, Kiyoshi Kita, Yusuke Tateno, Teruhisa Kato, Takaya Sakura, T. Shiba, D.K. Inaoka
This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.
bioRxiv · Oct 26, 2026 · PreprintMicrobiology