Stress-induced brain extracellular vesicles ameliorate anxiety behaviour.
Yusuke Mizohata, Yusuke Yoshioka, Minori Koga, Hiroyuki Toda, Hiroyuki Ohta, Yasunobu Kobayashi, Takahiro Ochiya, Yuji Morimoto
This study shows that stress-induced brain extracellular vesicles reduce anxiety in mice, and three miRNAs within these vesicles contribute to the anxiolytic effect by suppressing Mecp2 in neurons.
Translational Psychiatry · Nov 18, 2025Peer-reviewedAnimal Behavior & Cognition