Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency
Kenichi Miyata, Liying Yang, Yuxiao Yang, Kohei Kumegawa, Reo Maruyama
This study uses an integrated platform to show that ARID1A deficiency increases transcriptomic and epigenetic heterogeneity in cancer cells through stochastic and constrained chromatin changes.
bioRxiv · May 24, 2025 · PreprintCancer Biology