Biomolecular condensates provide a unique environment for redox-mediated protein crosslinking
H Y Wang, Bruna Favetta, Jinying Wang, Christian Hoffmann, Elton Maloku, Yuzhou Xia, Jean Baum, Dragomir Milovanović, Benjamin S. Schuster, Zheng Shi
This study shows that fluorescently tagged proteins in biomolecular condensates undergo crosslinking due to excitation-induced ROS, leading to condensate solidification and highlighting redox regulation of condensate properties.
bioRxiv · Apr 16, 2026 · PreprintBiophysics