Zheng Shi

This study quantifies how α-Synuclein monomers and seeds affect the material properties of Tau condensates, showing distinct effects on viscosity and interfacial tension.

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

This study shows that fluorescently tagged proteins in biomolecular condensates undergo crosslinking due to excitation-induced ROS, leading to condensate solidification and highlighting redox regulation of condensate properties.

This study uses lipidation to control biomolecular condensate properties and interactions, enabling the creation of multi-phase hydrogels that guide intestinal organoid morphogenesis.

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

This study shows amphiphilic surfactant proteins reduce interfacial tension of biomolecular condensates, with GST-based proteins being more effective due to higher surface density.

This study shows phosphorylation of SARS-CoV-2 N protein toggles its condensate state between membrane-wetting and engulfment, revealing a regulatory mechanism for viral RNA replication and packaging.

The paper identifies genes regulating alpha-synuclein homeostasis and shows their differential expression correlates with increased rare risk variant burden in Parkinson's disease.

The paper quantifies viscoelastic properties of synapsin condensates in live cells and identifies α-synuclein's role in regulating their material state.

This paper shows that membrane tension propagates along axons at 20 micrometers per second, influencing axon growth and branching through mechanical signaling.