Benjamin S. Schuster

Condensate Material Properties Influence Cargo Selection for Neuronal Extrusion via Large Extracellular Exopher Vesicles

The paper investigates how condensate material properties affect exopher cargo selection in neurons, finding that gel-like condensates are more efficiently recruited than liquid-like ones.

Biomolecular condensates provide a unique environment for redox-mediated protein crosslinking

This study shows that fluorescently tagged proteins in biomolecular condensates undergo crosslinking due to excitation-induced ROS, leading to condensate solidification and highlighting redox regulation of condensate properties.

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity

This study introduces β-sheet breaking proline residues into FUS prion-like domain to prevent aggregation and toxicity while preserving phase separation and function.

Gene Delivery Mediated by Backbone-Degradable RAFT Copolymers

This study develops backbone-degradable cationic copolymers for gene delivery, showing improved transfection efficiency without increased cytotoxicity.

POMPOMS: Crosslinked biomolecular condensates as a versatile platform for multifunctional protein microparticles.

The paper introduces POMPOMS, a method to create multifunctional protein microparticles by crosslinking biomolecular condensates, demonstrating controlled size and three functionalities.

Amphiphilic protein surfactants reduce the interfacial tension of biomolecular condensates

This study shows amphiphilic surfactant proteins reduce interfacial tension of biomolecular condensates, with GST-based proteins being more effective due to higher surface density.

Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States

This study shows phosphorylation of SARS-CoV-2 N protein toggles its condensate state between membrane-wetting and engulfment, revealing a regulatory mechanism for viral RNA replication and packaging.

Controlled and orthogonal partitioning of large particles into biomolecular condensates

This study demonstrates that large particles can be controlled and orthogonally partitioned into biomolecular condensates through strong particle-condensate interactions, using polymer nanoparticles with tailored surface chemistries.

Revealing nanoscale structure and interfaces of protein and polymer condensates via cryo-electron microscopy

This study uses cryo-EM to analyze nanoscale structures of protein and polymer condensates, revealing core-shell morphologies and internal inhomogeneities.