Mechanical-control of cell proliferation increases resistance to chemotherapeutic agents
I. Rizzuti, P. Mascheroni, S. Arcucci, Z. Ben-Meriem, A. Prunet, C. Barentin, C. Riviere, H. Delanoe-Ayari, H. Hatzikirou, J. Guillermet-Guibert, M. Delarue
The paper shows that compressive stress in pancreatic cancer spheroids reduces chemotherapeutic efficacy by decreasing cell proliferation.
bioRxiv · Jan 18, 2020Cancer Biology