J. Guillermet-Guibert

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration.

This study shows that meat-enriched diets and inflammation promote pancreatic cell plasticity via PI3Kα, which limits tissue regeneration and increases cancer risk.

An easy-to-use microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding

This paper introduces a microfluidic device that enables controlled mechanical and chemical environments for studying biological samples, showing that confined growth increases macromolecular crowding.

The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic Capacity

This paper shows that TRIP12 loss inhibits pancreatic acinar cell plasticity and tumor metastasis by affecting Claudin18.2 expression and ADM.

Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence and late clinical metastasis in a Beclin-1-dependent manner.

This study shows that mTOR regulates self-sustained quiescence in cancer cells, which contributes to tumor indolence and late metastasis through Beclin-1 dependence.

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

This study identifies adaptive phosphoprotein responses to isoform-selective PI3K inhibitors in pancreatic cancer, showing that combination therapy can overcome resistance.

The lipid kinase PI3Kα is required for the cohesion and survival of cancer cells disseminated in serous cavities.

This study shows that PI3Kα is essential for the cohesion and survival of cancer cells in serous cavities, suggesting it as a therapeutic target.

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

Mechanical-control of cell proliferation increases resistance to chemotherapeutic agents

The paper shows that compressive stress in pancreatic cancer spheroids reduces chemotherapeutic efficacy by decreasing cell proliferation.