Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells
Z. H. Walsh, P. Shah, N. Kothapalli, G. Nikolenyi, S. Shah, G. Leuzzi, M. Mu, P. Ho, S. Abuzaid, Z. D. Brodtman, N. Vasan, M. N. AlQuaraishi, J. D. Milner, A. Ciccia, J. C. Melms, B. Izar
This study uses base editing to screen for variants affecting T cell anti-tumor functions, identifying mutations that enhance tumor elimination with minimal off-target effects.
bioRxiv · Dec 13, 2023 · PreprintImmunology