Author

P. Ho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2 Microbiology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Organism:bacteria (other)· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

B. Izar· 2 shared J. A. Bluestone· 2 shared J. A. Wells· 2 shared J. C. Melms· 2 shared J. Eyquem· 2 shared L. M. R. Ferreira· 2 shared M. Mu· 2 shared N. Vasan· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

B. Izar

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells

Z. H. Walsh, P. Shah, N. Kothapalli, G. Nikolenyi, S. Shah, G. Leuzzi, M. Mu, P. Ho, S. Abuzaid, Z. D. Brodtman, N. Vasan, M. N. AlQuaraishi, J. D. Milner, A. Ciccia, J. C. Melms, B. Izar

This study uses base editing to screen for variants affecting T cell anti-tumor functions, identifying mutations that enhance tumor elimination with minimal off-target effects.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

Y. Wu, Z. Huang, Y. Liu, C.-W. Yoon, K. Sun, Y. Situ, P. Ho, Z. Yuan, L. Zhu, J. Eyquem, Y. Zhao, T. Liu, G. A. Kwong, S. Chien, Y. Wang

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

bioRxiv · Jun 21, 2023 · PreprintBioengineering

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

W. L. Lee, A. Sinha, L. N. Lam, H. L. Loo, J. Liang, P. Ho, C. Liang, C. Chan, T. Begley, K. A. Kline, P. Dedon

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Bacteriophage anti-defense genes that neutralize TIR and STING immune responses

P. Ho, Y. Chen, S. Biswas, E. Canfield, D. E. Feldman

The paper identifies bacteriophage nucleotidyltransferases and anti-TIR defense genes that inhibit TIR-STING immune responses to promote viral propagation.

bioRxiv · Jun 9, 2022 · PreprintMicrobiology

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity

P. Ho, J. C. Melms, M. Rogava, C. J. Frangieh, S. B. Shah, Z. Walsh, O. Kyrysyuk, A. D. Amin, L. Caprio, B. T. Fullerton, R. Soni, C. R. Ager, J. Biermann, Y. Wang, M. Mu, , B. Izar

The paper identifies the CD58:CD2 axis as co-regulated with PD-L1 via CMTM6 and shows its role in anti-tumor immunity, proposing therapeutic strategies to enhance immunotherapy.

bioRxiv · Mar 21, 2022 · PreprintCancer Biology

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance

Y. D. Muller, L. M. R. Ferreira, E. Ronin, P. Ho, V. Nguyen, G. Faleo, Y. Zhou, K. Lee, K. K. Leung, N. Skartsis, A. M. Kaul, A. Mulder, F. H. J. Claas, J. A. Wells, J. A. Bluestone, Q. Tang

This paper develops an anti-HLA-A2 CAR for Tregs to induce transplant tolerance, showing they target HLA-A2-expressing grafts and suppress immune rejection.

bioRxiv · Aug 16, 2021Immunology

The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcome

K. Masuda, A. Kornberg, S. Lin, P. Ho, K. Secener, N. Suek, A. M. Bacarella, M. Ingham, V. Rosario, A. M. Al-Masrou, S. A. Lee-Kong, P. R. Kiran, K. S. Yan, M. Stoeckius, P. Smibert, , A. Han

The paper analyzes T-cell infiltration in colorectal cancer, identifying prognostic and non-prognostic T cell subtypes and their clinical implications.

bioRxiv · Sep 27, 2020 · PreprintImmunology

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

Y. Muller, D. Nguyen, L. M. R. Ferreira, P. Ho, C. Raffin, R. Beltran Valencia, Z. Congrave-Wilson, T. Roth, J. Eyquem, F. Van Gool, A. M. R. Marson, J. A. Wells, J. A. Bluestone, Q. Tang

This paper shows that CD28-TMD in CARs forms heterodimers with endogenous CD28, affecting T-cell responses and surface expression.

bioRxiv · Sep 18, 2020Bioengineering

Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

T. Azarian, P. Mitchell, M. Georgieva, C. M. Thompson, A. Ghoulia, A. J. Pollard, A. von Gottberg, M. du Plessis, M. Antonio, B. A. Kwambana-Adams, S. C. Clarke, D. Everett, J. Cornick, E. Sadowy, W. Hryniewicz, , W. P. Hanage

This study analyzes global serotype 3 pneumococcal isolates to show a recent emergence of Clade II with antibiotic resistance and antigenic diversity, not linked to PCV13 usage.

bioRxiv · Jun 27, 2018Evolutionary Biology