An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity
L. A. Luna, Z. Lesecq, K. A. White, A. Hoang, D. A. Scott, O. Zagnitko, A. A. Bobkov, D. L. Barber, J. M. Schiffer, D. G. Isom, C. D. Sohl
This paper identifies an acidic residue in IDH1 that regulates catalysis and pH sensitivity through conformational changes.
bioRxiv · Apr 19, 2020Biochemistry