Author

Z. Maliga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Assay:imaging· 3 Approach:microscopy & imaging analysis· 3 Assay:spatial transcriptomics· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

A. J. Nirmal· 5 shared S. Santagata· 5 shared G. F. Murphy· 4 shared P. K. Sorger· 4 shared Y.-A. Chen· 4 shared C. G. Lian· 3 shared C. Yapp· 3 shared A. A. Chen· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCancer Biology

A. J. Nirmal

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Author profile →

6 papers

Recent·Most cited

Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours

C. Yapp, A. J. Nirmal, F. Y. Zhou, A. Y. H. Wong, J. Tefft, Y. D. Lu, Z. Shang, Z. Maliga, P. Montero Llopis, G. F. Murphy, C. Lian, G. Danuser, S. Santagata, P. K. Sorger

This paper introduces 3D CyCIF, a method for high-plex 3D profiling of cell states and immune niches in human tumors, revealing detailed spatial interactions and cytokine niches previously unattainable in thin sections.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence

Z. Maliga, D. Y. Kim, A.-T. N. Bui, J.-R. Lin, A. K. Dewan, G. F. Murphy, A. J. Nirmal, C. G. Lian, P. K. Sorger, N. R. LeBoeuf

This study compares CyCIF and IHC for immune profiling in ICI-induced dAEs, finding CyCIF provides more detailed single-cell characterization of immune infiltrates.

bioRxiv · Apr 3, 2023 · PreprintImmunology

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution

A. J. Nirmal, Z. Maliga, T. Vallius, B. Quattrochi, A. A. Chen, C. A. Jacobson, R. J. Pelletier, C. Yapp, R. Arias-Camison, Y.-A. Chen, C. G. Lian, G. F. Murphy, S. Santagata, P. K. Sorger

The paper uses spatial techniques to study immune evasion and immunoediting in primary melanoma, finding localized immunosuppressive environments and coexistence of invasion and regression.

bioRxiv · May 23, 2021Cancer Biology

Micro-region transcriptomics of fixed human tissue using Pick-Seq

Z. Maliga, A. J. Nirmal, N. G. Ericson, S. A. Boswell, L. U'Ren, R. Podyminogin, J. Chow, Y.-A. Chen, A. A. Chen, D. M. Weinstock, C. G. Lian, G. F. Murphy, E. P. Kaldjian, S. Santagata, P. K. Sorger

Pick-Seq enables deep spatial transcriptomic profiling of fixed human tissue, revealing transcriptional differences in tumor invasion, proliferation, and immuno-editing.

bioRxiv · Mar 18, 2021 · PreprintCancer Biology

Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

M. Kalocsay, Z. Maliga, A. J. Nirmal, R. J. Eisert, G. A. Bradshaw, I. H. Solomon, Y.-A. Chen, R. J. Pelletier, C. A. Jacobson, J. Mintseris, R. F. Padera, A. J. Martinot, D. H. Barouch, S. Santagata, P. Sorger

The paper uses multiplexed proteomics and imaging to compare inflammatory and thrombotic responses in resolving SARS-CoV-2 infection in rhesus macaques and lethal COVID-19 in humans.

bioRxiv · Oct 14, 2020 · PreprintPathology

Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer

R. Rashid, G. Gaglia, Y.-A. Chen, J.-R. Lin, Z. Du, Z. Maliga, D. Schapiro, C. Yapp, J. Muhlich, A. Sokolov, P. Sorger, S. Santagata

The paper describes a dataset of multiplexed immunofluorescence images and single-cell immune marker data from human tonsil and lung cancer tissues, along with analysis methods and tools.

bioRxiv · Jul 17, 2019Cancer Biology