Author

A. J. Martinot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. H. Barouch· 5 shared J. Yu· 4 shared A. Chandrashekar· 3 shared A. Cook· 3 shared E. Teow· 3 shared H. Andersen· 3 shared J. Velasco· 3 shared K. McMahan· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

D. H. Barouch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Attenuated Mycobacterium tuberculosis Vaccine Protection in a Low Dose Murine Challenge Model

S. J. Vidal, D. Sellers, J. Yu, S. Wakabayashi, J. Sixsmith, M. Aid, J. Barrett, S. F. Stevens, X. Liu, W. Li, C. R. Plumlee, K. B. Urdahl, A. J. Martinot, D. H. Barouch

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

bioRxiv · Mar 17, 2023 · PreprintMicrobiology

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

A. Chandrashekar, J. Yu, K. McMahan, C. Jacob-Dolan, J. Liu, X. He, D. Hope, T. Anioke, J. Barrett, B. Chung, N. Hachmann, M. Lifton, J. Miller, O. Powers, M. Sciacca, , D. H. Barouch

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

bioRxiv · Feb 6, 2022Microbiology

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response.

A. E. Hinman, C. Jani, S. C. Pringle, W. R. Zhang, N. Jain, A. J. Martinot, A. K. Barczak

The paper identifies a late TLR2-dependent transcriptional response in macrophages to Mycobacterium tuberculosis mutants and shows how virulence factors interfere with this response to promote TB pathogenesis.

bioRxiv · Oct 6, 2021 · PreprintMicrobiology

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

N. C. Dalvie, L. H. Tostanoski, S. A. Rodriguez-Aponte, K. Kaur, S. Bajoria, O. Kumru, A. J. Martinot, A. Chandrashekar, K. McMahan, N. B. Mercado, J. Yu, A. Chang, V. M. Giffin, F. Nampanya, S. Patel, , D. H. Barouch

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

bioRxiv · Jul 13, 2021 · PreprintImmunology

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

X. He, A. Chandrashekar, R. C. Zahn, F. Wegmann, J. Yu, N. B. Mercado, K. McMahan, A. J. Martinot, C. Piedra-Mora, S. Beecy, S. Ducat, R. Chamanza, S. Rosendahl Huber, L. van der Fits, E. N. Borducchi, , D. H. Barouch

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

bioRxiv · Jan 27, 2021Immunology

Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

M. Kalocsay, Z. Maliga, A. J. Nirmal, R. J. Eisert, G. A. Bradshaw, I. H. Solomon, Y.-A. Chen, R. J. Pelletier, C. A. Jacobson, J. Mintseris, R. F. Padera, A. J. Martinot, D. H. Barouch, S. Santagata, P. Sorger

The paper uses multiplexed proteomics and imaging to compare inflammatory and thrombotic responses in resolving SARS-CoV-2 infection in rhesus macaques and lethal COVID-19 in humans.

bioRxiv · Oct 14, 2020 · PreprintPathology