The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chains
A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda
This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.
bioRxiv · May 27, 2020Biochemistry