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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
I. Schwartz, V. Budroni, M. Meyenberg, H. Hornegger, K. Hacker, S. Schwartz, Z. Hodakova, D. B. Grabarczyk, J. Ehrmann, S. Scinicariello, D. Haselbach, J. Menche, T. Clausen, E. Karagoez, G. A. Versteeg
The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.
bioRxiv · Apr 23, 2024Cell Biology
J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen
The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.
bioRxiv · Aug 30, 2022 · PreprintBiochemistry
S. Scinicariello, A. Soederholm, M. Schaefer, A. Shulkina, I. Schwartz, K. Hacker, R. Gogova, R. Kalis, K. Froussios, V. Budroni, A. Bestehorn, T. Clausen, P. Kovarik, J. Zuber, G. A. Versteeg
This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.
bioRxiv · Aug 29, 2022Cell Biology
A. Vogel, R. Arnese, R. Gudino Carrillo, D. Sehr, A. Bylicki, A. Meinhart, T. Clausen
This study identifies the FX3HY motif as essential for UNC-45-mediated myosin folding, linking its disruption to Freeman Sheldon Syndrome and myopathies.
bioRxiv · Aug 8, 2022Biochemistry
L. Picchianti, V. Sanchez de Medina Hernandez, N. Zhan, N. A. T. Irwin, M. Stephani, H. Hornegger, R. Beveridge, J. Sawa-Makarska, T. Lendl, N. Grujic, S. Martens, T. A. Richards, T. Clausen, S. Ramundo, E. G. Karagoz, Y. Dagdas
The paper shows that non-canonical shuffled ATG8 interacting motifs in C53 link UFMylation and autophagy, revealing an ancestral regulatory mechanism for ER homeostasis.
bioRxiv · Apr 26, 2022Plant Biology
F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen
This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.
bioRxiv · Jun 9, 2021Biochemistry
J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen
This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.
bioRxiv · May 10, 2021Biochemistry
M. Stephani, L. Picchianti, A. Gajic, R. Beveridge, E. Skarwan, V. Sanchez de Medina Hernandez, A. Mohseni, M. Clavel, Y. Zeng, C. Naumann, M. Matuszkiewicz, E. Turco, C. Loefke, B. Li, G. Durnberger, , Y. Dagdas
The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.
eLife · Aug 27, 2020Peer-reviewedCell Biology
A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda
This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.
bioRxiv · May 27, 2020Biochemistry
R. Beveridge, D. Kessler, K. Rumpel, P. Ettmayer, A. Meinhart, T. Clausen
This study shows native mass spectrometry can detect PROTAC-mediated protein interactions and identify preferred E3-PROTAC-POI combinations in competition experiments.
bioRxiv · Nov 25, 2019Biochemistry