Author

F. Ikeda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

K. Mechtler· 3 shared L. Deszcz· 3 shared A. Kavirayani· 2 shared K. Schodl· 2 shared L. M. Fennell· 2 shared T. Clausen· 2 shared A. Abdrakhmanov· 1 shared A. Bestehorn· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

K. Mechtler

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

C. Gomez Diaz, G. Jonsson, K. Schodl, L. Deszcz, A. Bestehorn, K. Eislmayr, J. Almagro, A. Kavirayani, L. M. Fennell, A. Hagelkrueys, P. Kovarik, J. M. Penninger, F. Ikeda

This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.

bioRxiv · Apr 13, 2021Cell Biology

The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chains

A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda

This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.

bioRxiv · May 27, 2020Biochemistry

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

M. Stephani, L. Picchianti, A. Gajic, R. Beveridge, E. Skarwan, V. Sanchez de Medina Hernandez, A. Mohseni, M. Clavel, Y. Zeng, C. Naumann, M. Matuszkiewicz, E. Turco, C. Loefke, B. Li, G. Durnberger, , Y. Dagdas

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

bioRxiv · Mar 18, 2020Cell Biology

Site-specific ubiquitination of the E3 ligase HOIP regulates cell death and immune signaling

L. M. Fennell, L. Deszcz, A. Schleiffer, K. Mechtler, A. Kavirayani, F. Ikeda

This study identifies that site-specific ubiquitination of HOIP at K784 regulates TNF-induced inflammatory signaling and cell fate by modulating TNFR complex formation and LUBAC activity.

bioRxiv · Aug 21, 2019Cell Biology